Posted: Fri, May 31, 2013 | By: Anti-Aging / Supplements
by David Emil Lombard
If you are reading TA-65 reviews, you’ve either look for ways to age gracefully, or you’re intrigued as the the best way to slow down the process.
You’ve probably read some of the TA-65 reviews and you’re wondering if its the most effective way support youthful aging.
Reading these TA-65 reviews, you also may be wondering if there are any more effective proven products that serve the same function.
this essay was first published at David’s blog HERE
Keep reading to find out what the top researcher & chief consultant to TA Sciences have done since they discovered TA-65. It is exciting and I have definitely upgraded.
We should probably start with some basics and objectively clear up any misconceptions by answering the questions: What is a telomere and what function does it serve?
Simply put, telomeres protect chromosomes.
Chromosomes are basically long, organized strands of DNA and proteins found in your cells. These strands dictate all the processes that occur in your cells. The proper placement and functioning of chromosomes can predispose people to a normal, healthy functioning body. Chromosomes also have hereditary indicators that play important roles in the development of a person.
At each end of every chromosome strand, you have a telomere. Think of telomeres like bookends. Much like bookends are used to hold a row of books upright and in place on a shelf, our telomeres keep the chromosomes safe and intact. Telomeres keep the chromosomes from becoming frayed, from fusing into rings, or binding with other DNA. (Other TA-65 reviews probably won’t tell you it was designed to aid in these functions. Always consider the source you take advice from.)
While looking at TA-65 reviews, remember it is also important to truly grasp what cellular aging really means.
Cells keep our body going. They supply us energy, heal our wounds, and are the foundation of our organs. With such an important role, you can see how keeping cells functioning in top form as long as possible is vital to healthy living. If cells are no longer able to replicate, if the body’s ability to defend and repair itself is compromised, you are vulnerable to the complications of aging.
Do any of the TA-65 reviews suggest the supplement really assists in replication?
To understand the aging process, it’s important to take a look at the cellular level to discover exactly how our cells age, and what impacts the aging process.
The first big piece is looking at how effective TA-65 is in battling free radicals.
Every day, free radicals are formed inside our bodies through standard, necessary chemical reactions. We also absorb free radicals through pollution, UV radiation, x-rays, second hand smoke, and through our own actions via stress, smoking, and weight gain.
Over-exposure to free radicals damages not only our cells’ ability to function properly, but also the integrity of our cells’ overall composition. This results in the following generation’s cells being less healthy and less productive than the cells they came from. As we age, the number of mistakes incurred by daily cellular reproduction increases. The body actually creates nonfunctional cells, leading to more rapid deterioration of the body’s functions. As this process goes on, it creates an increase in oxidative stress.
The next big piece in understanding cellular aging as you are reading TA-65 reviews, is increased oxidative stress.
Our bodies are constantly reacting with the air we breathe. We take in oxygen, as well as tons of other pollutants and toxins in our environment. As we breathe and eat, our body utilizes the oxygen and food to help create energy. The energy-creating process, as well as the pollutants in our environment, create highly reactive molecules. These molecules are called free radicals. When free radicals interact with other molecules within the cellular structure, damage to proteins, membranes and DNA can occur.
Oxidative stress occurs when there is an imbalance in a cell’s production and handling of free radicals and its natural ability to repair the damage caused by the exposure. Telomere shortening is accelerated by oxidative stress and inflammation. Both of these processes are affected by diet and lifestyle. Thus, its important when looking at TA-65 reviews, to examine how effective it is at battling oxidative stress. The secret will be in how many active ingredients TA-65 has do that.
With a few exceptions, the natural process for human growth and healing involves cells dividing. Cells divide primarily to grow or heal the body by replacing worn out cells with new cells.
Telomeres play an important role in cell division. Each time a cell divides, the DNA unwraps and the information in the DNA is copied. When the cell is finished dividing, the DNA comes back together and telomeres re-assume their protective roles at the ends of the chromosomes.
Unfortunately, telomeres lose a little bit of length each time this happens, like a pencil eraser gets shorter each time it’s used. As you read TA-65 reviews, you’re most likely wondering if it really helps more in the process of strengthening cell division than the other product on the market that we’ve discovered.
Scientists have noticed that cells stop replicating when telomeres become too short. Without adequate telomere protection, essential parts of the DNA can be damaged in the replication process. In humans, a cell replicates approximately 40-60 times before the telomeres become too short. This limit is called the Hayflick Phenomenon (or limit). Research has shown the more a cell divides, the shorter the telomeres get, and the less time the cell will be productive and able to divide.
The majority of the work is done by the body’s own master antioxidant, glutathione, and antioxidant enzymes including glutathione peroxidase, catalase, and superoxide dismutase. Its essential to find food sources containing these. When telomeres shorten and fray, recent research suggests that these antioxidant defenses diminish and protection against free radicals weakens.
Does TA-65 prevent this?
Emerging research reveals we may be able to influence cellular aging processes in positive ways. This may affect how efficiently cells repair and replicate themselves, which affects your health, well-being and the aging process in various ways.
What we found out was - many of these protective nutrients and compounds were not found in TA-65 reviews.
Fortunately, we discovered another alternative that appears to be a far superior alternative to TA-65, and a much more affordable one for those desiring to feel younger again. Before we get there, its important to highlight this recent research so you can make your own decision.
With the recent surge of interest in telomere shortening as an underlying cause of aging, it’s no wonder scientists are enthusiastically researching how diet and lifestyle can influence telomere length. Ligi Paul, Ph.D., of the USDA Human Nutrition Research Center on Aging at Tufts University, has reviewed the latest literature associating telomere length with nutrients, bioactive compounds, and lifestyle factors.
Telomeres protect the ends of chromosomes from fusing with each other, Dr. Paul reminds us, and their length is an indicator of biological aging. Although shortening is a normal part of aging, oxidative stress and inflammation definitely speed up the process of telomere shortening.
“Of interest to nutritionists, telomere length has been shown to be associated with nutritional status in human and animal studies. Healthy lifestyles and diets are positively correlated with telomere length,” Dr. Paul wrote. According to his review, the most recent studies have found that the following nutrients influence telomere length:
* Folate – This B vitamin is important for DNA and RNA structure and function.
* Vitamin B12 – In conjunction with folate, this B vitamin is important for the methylation, or detoxification, of homocysteine. Higher levels of homocysteine are associated with increased oxidative stress.
* Niacin (nicotinamide) – Can influence telomere length through its multiple regulatory and co-enzymatic activities.
* Vitamin A and beta-carotene – These antioxidants reduce concentrations of harmful signaling molecules and increase beneficial ones to help reduce oxidative stress.
* Vitamin D – Higher levels of vitamin D lower levels of c-reactive protein (CRP), a protein with harmful effects and associated with shortened telomere length. Vitamin D appears to inhibit some of CRP’s harmful effects.
* Vitamins C and E – These antioxidant vitamins are widely acknowledged for limiting oxidative stress and its damage on DNA and telomeres.
* Magnesium – The mineral required for the activity of a number of enzymes involved in DNA replication and repair. Low amounts of this mineral are also associated with higher concentrations of CRP.
* Zinc – This mineral is necessary for a variety of enzymes including DNA polymerases, which are important for DNA and telomere maintenance.
* Iron – In contrast to the other nutrients, iron supplementation is associated with shorter telomeres. This is likely because of iron’s pro-oxidant ability to stimulate free radical generation. While iron supplements may increase oxidative stress, iron from diet or multivitamins (containing less iron) is not negatively associated with telomere length.
* Curcumin and turmeric – Turmeric, and its primary component curcumin, are common dietary spices that stimulate synthesis of antioxidants, thereby protecting against oxidative stress. Mice fed diets containing curcumin had a trend for longer telomeres compared with controls.
* Long-chain omega-3 fatty acids (fish oil) – Higher plasma levels of long-chain omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) may protect against oxidative stress by enhancing activity of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase.
* Polyphenols – Polyphenols from grape seed and green tea provide additional protection for DNA and telomeres from oxidative stress. Those who drink tea regularly have longer telomeres while mice fed grape seed polyphenols had longer telomeres compared to controls.
Upon further investigation, our TA-65 reviews show that it doesn’t contain any of these proven organic botanicals proven to lengthen telomeres.
In addition to natural ingredients that support telomere length, the key is natural activation of telomerase in the human body.
Dr. Bill Andrews and his team at Sierra Sciences were the first to do this and have exclusively partnered with ‘The Mineral Man,’ John Anderson. His team that built this research won the Noble Prize in Medicine in 2009. Bill Andrews and John Anderson were featured in a 12 page spread in Popular Science magazine for their groundbreaking work in August, 2011. The title of the article was, “The Man Who Stopped Time.”
Dr. Bill and his team at Sierra Sciences found its first telomerase inducer called C0057684. It was the first ever discovered that activates the telomerase enzyme gene without killing the cells. In addition, C0057684 provided Sierra Sciences with the first positive control ever for detection of telomerase gene activity in normal human cells. This has served as a very powerful tool for the development of robust high throughput screening assays for finding additional telomerase inducers.
What’s most notable is that before meeting master herbalist & ‘mineral man’, John Anderson, Dr. Bill Andrews and Sierra Sciences only found one hit that activated telomerase in the human body that protects telomeres; much like TA-65 and their one plant phytochemical.
Unlike TA-65, after working with John Anderson, Dr. Bill Andrews and his team have found the following:
“We have screened 254,593 compounds. We have found 858 telomerase inducers.”
Before partnering with John, it would take Bill and his team 10,000 tries to get a hit that would induce telomerase. Out of the first 11 organic plant compounds John sent to Bill and his team (triple blind so they wouldn’t know) to test, they got 8 hits activating telomerase. That is already 7 above TA-65.
In our TA-65 reviews, what we’ve found is that it only uses one telomerase activator, Astragalus. TA-65 is a naturally occurring single molecule found in the ancient Chinese herb Astragalus. T.A. Sciences has developed a proprietary process to refine and purify TA-65. Their process begins with tons of plant material harvested from selected farms in one small region in China.
Sierra Sciences, partnering exclusively with John Anderson and his team in creating its groundbreaking telomere support supplement - Product B - has found 858 telomerase inducers, as opposed to 1 telomerase activator in the TA-65 product.
It seems Dr. Bill Andrews and John Anderson clearly have the superior firepower, and far more testimonials to back it up, but what about the cost comparison to TA-65?
Product B can be purchased at wholesale for as little as $69. Conversely, a monthly supply of TA-65 comes to $219. Pretty much a no-brainer from a cost stand point.
I’ve also found significantly more testimonials for Product B than with TA-65 reviews.
In my opinion, based on weighing the science and the facts, TA-65 is a stellar product, but we found Product B to be far superior.
(this essay was first published at David’s blog HERE That link also provides information on where to buy Product B)
1. Paul L. Diet, nutrition and telomere length. J Nutr Biochem 2011. doi: 10.1016/j.jnutbio.2010.12.001
Dr. Bill Andrews, Sierra Sciences, 2011 http://SierraSci.com
2. Hayflick L. (1965). The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37 (3): 614-636.
3. Olovnikov AM. Principle of marginotomy in template synthesis of polynucleotides. Doklady Akademii nauk SSSR. 1971; 201(6):1496-9.Â Watson, J. D. Origin of concatemeric T7 DNA. Nat New Biol. 1972; 239(94):197-201.
4. Cawthon, R. M., K. R. Smith, et al. (2003). “Association between telomere length in blood and mortality in people aged 60 years or older.” Lancet 361(9355): 393-5.
5. Adapted from: Tsuji, A., A. Ishiko, et al. (2002). “Estimating age of humans based on telomere shortening.” Forensic Sci Int 126(3): 197-9.
6. Bodnar, et al. Extension of life-span by introduction of telomerase into normal human cells. Science, 1998.
7. Funk, et al. Telomerase Expression Restores Dermal Integrity to in Vitro-Aged Fibroblasts in a Reconstituted Skin Model. Experimental Cell Research, 2000
8. Tomas, et al. Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice. Cell, 2008.
9. Jiang, X.-R. et al. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nature Genet., 21, 111-114 (1999); Morales, C.P., et. al. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nature Genet., 21, 115-118 (1999); Harley, C. B. Telomerase is not an oncogene. Oncogene 21(4): 494-502 (2002). TA 65